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General description:
This mouse model has been created by intravenously injecting bone marrow-homing mouse myeloma cells (MOPC-315.BM) that expressed luciferase into BALB/c wild type mice. The luciferase in the myeloma cells allows e.g. in vivo tracking before and after melphalan treatment with bioluminescence imaging (BLI). Homing of MOPC-315.BM luciferase+ myeloma cells to specific tissues has been examined by flow cytometry. Idiotype-specific myeloma protein serum levels have also been measured by ELISA, and in vivo measurements have been validated with histopathology.
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