Rat NKp46SKU: P-258

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General description: 

Mouse anti-rat NKp46 monoclonal antibody (Clone WEN23).

Applications: FACS, Western blot, Immunoprecipitation, Immunohistochemistry

Isotype: IgG1

Rat NKp46 is an activating receptor expressed on all NK cells in all rat strains tested. NKp46 is the defining surface marker for rat NK cells. No expression of NKp46 has so far been reported on non-NK cells in the rat. NKp46 associates with the activating adaptor proteins FcepsilonRIgamma and CD3zeta and activates NK cell cytotoxicity and IFNgamma production.

About the scientist

Erik Dissen

Professor

The main focus of this research group is to understand at the molecular and cellular levels how NK cells discriminate between these different target cells. This includes identification of NK cell receptors, signaling pathways and linked effector mechanisms, ligand molecules recognized by NK receptors as well as the mechanisms that lead to ligand expression.