Rat Ly49s3SKU: P-259

Link to publication: 
Go to publication
General description: 

Rat anti-rat Ly49s3 monoclonal antibody (clone STOK6)

Applications: Flow cytometry

Isotype: Rat IgG2b

Ly49s3 is an activating C-type lectin-like receptor expressed on approximately 30% of splenic NK cells in the high ALC responder strains PVG, AO, and LOU/C. Ly49s3 is most likely an MHC class Ib receptor, as it is down modulated on the cell surface in the presence of its putative MHC ligands in the n, c, lv1, av1, and l, but not u MHC haplotypes.

UniProt codes: 

Q5MPX1

Q5MPW9

 

About the scientist

Lise Kveberg

Post doctoral fellow

The NK research group (NKRG) focuses on the biology and recognition mechanisms of Natural Killer (NK) cells, which constitute an important part of our innate immune defense against neoplastic and virally infected cells, and react with normal allogeneic cells. One main focus is on the characterization of several families of lectin-like receptors on NK cells and their roles in immune responses against diseased cells.

Group leader: John T. Vaage, Department head, Professor

ttp://www.ous-research.no/vaage/

http://www.med.uio.no/klinmed/personer/adm/lisek