Mouse anti-rat KLRE1 monoclonal antibody (Clone WEN35).
Applications: FACS. Not yet tested in Western blotting and immunoprecipitation.
Isotype: IgG1.
Clone WEN35 replaces clone WEN27, that loses reactivity upon NHS-conjugation to fluorochromes. KLRE1 is a lectin-like receptor expressed on NK cells and subsets of T cells. The protein associates with members the KLRI family, to form functional cell surface-expressed receptors that either inhibit (KLRE/I1) or activate (KLRE/I2) NK cell cytotoxicity (http://www.ncbi.nlm.nih.gov/pubmed/18713988). KLRE1 deficient mice display reduced NK cell mediated alloreactivity towards bone marrow transplants (http://www.ncbi.nlm.nih.gov/pubmed/15069013).