Rat NKG2A/C/ESKU: P-82

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General description: 

Mouse Anti-rat NKG2A/C/E monoclonal antibody (clone WEN28).

Applications: FACS, Immunoprecipitation, Western Blot.

Isotype: IgG1.

The WEN28 mAb binds to rat NKG2A, NKG2C and NKG2E. These receptor chains associate with the invariant receptor chain CD94 to form functional receptors expressed on most Natural Killer (NK) cells and subsets of T cells. Rat CD94/NKG2A is an inhibitory receptor whereas CD94/NKG2C and CD94/NKG2E are activating receptors. Unlike human CD94, rat and mouse CD94 associate directly with the signalling adaptor proteins DAP10 and DAP12.

About the scientist

Per Christian Sæther

Post. Doc

I have 15 years of experience as a scientist with immunology as the primary field of interest. Most of my projects concern the immune response of natural killer cells. These cells have an extraordinary ability to kill cells infected with viruses and cells that have transformed into cancer cells. Thus, natural killer cells constitute a crucial part of the immune response in intracellular infections and cancer.
I study how natural killer cells uses surface receptors to recognize sick cells, and how intracellular signals from these receptors translate into effector responses. The ultimate goal is to gain knowledge that translate into efficent ways to use natural killer cells in immunotherapy treatments.

During my studies, I have gained experience in a broad spectre of laboratory techniques. These techniques include methods to study the phenotype and responses of immune cells, as well as different methods to study DNA, RNA and proteins.