This mouse model has been created by intravenously injecting bone marrow-homing mouse myeloma cells (MOPC-315.BM) that expressed luciferase into BALB/c wild type mice. The luciferase in the myeloma cells allows e.g. in vivo tracking before and after melphalan treatment with bioluminescence imaging (BLI). Homing of MOPC-315.BM luciferase+ myeloma cells to specific tissues has been examined by flow cytometry. Idiotype-specific myeloma protein serum levels have also been measured by ELISA, and in vivo measurements have been validated with histopathology.
MOPC315.BM Luciferase+ - multiple myelomaSKU: C-77
About the scientist
Bjarne Bogen has an interest in immunology of T and B lymphocytes, autoimmune diseases, immunosurveillance of cancer, and development of more powerful vaccines.