Rat Ly49s5 / i5SKU: A-271

General description: 

Mouse anti-rat Ly49s5/i5 monoclonal antibody (Clone Fly5)

Applications: Flow cytometry

Isotype: Mouse IgG1

Rat Ly49 receptors are a large family of C-type lectin-like receptors encoded in the NK gene complex on rat chromosome 4. Ly49s5 and Ly49i5 are two structurally related receptors with opposing function; Ly49s5 is activating and Ly49i5 is inhibitory. They both bind nonclassical MHC I molecules. The Fly5 antibody binds 5-16% of NK cells and 10-37% of NKT cells in the spleen, and the size of the Fly5+ populations are strain dependent.

UniProt codes:

Q5DLU5_RAT

Q5MPV0_RAT

About the scientist

Lise Kveberg

Post doctoral fellow

The NK research group (NKRG) focuses on the biology and recognition mechanisms of Natural Killer (NK) cells, which constitute an important part of our innate immune defense against neoplastic and virally infected cells, and react with normal allogeneic cells. One main focus is on the characterization of several families of lectin-like receptors on NK cells and their roles in immune responses against diseased cells.

Group leader: John T. Vaage, Department head, Professor

ttp://www.ous-research.no/vaage/

http://www.med.uio.no/klinmed/personer/adm/lisek