Mouse anti-rat Ly49s5/i5 monoclonal antibody (Clone Fly5)
Applications: Flow cytometry
Isotype: Mouse IgG1
Rat Ly49 receptors are a large family of C-type lectin-like receptors encoded in the NK gene complex on rat chromosome 4. Ly49s5 and Ly49i5 are two structurally related receptors with opposing function; Ly49s5 is activating and Ly49i5 is inhibitory. They both bind nonclassical MHC I molecules. The Fly5 antibody binds 5-16% of NK cells and 10-37% of NKT cells in the spleen, and the size of the Fly5+ populations are strain dependent.