Rat KLRE1SKU: P-83

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General description: 

Mouse anti-rat KLRE1 monoclonal antibody (Clone WEN35).

Applications: FACS. Not yet tested in Western blotting and immunoprecipitation.

Isotype: IgG1.

Clone WEN35 replaces clone WEN27, that loses reactivity upon NHS-conjugation to fluorochromes.  KLRE1 is a lectin-like receptor expressed on NK cells and subsets of T cells. The protein associates with members the KLRI family, to form functional cell surface-expressed receptors that either inhibit (KLRE/I1) or activate (KLRE/I2)  NK cell cytotoxicity (http://www.ncbi.nlm.nih.gov/pubmed/18713988). KLRE1 deficient mice display reduced NK cell mediated alloreactivity towards bone marrow transplants  (http://www.ncbi.nlm.nih.gov/pubmed/15069013).

About the scientist

Per Christian Sæther

Post. Doc

I have 15 years of experience as a scientist with immunology as the primary field of interest. Most of my projects concern the immune response of natural killer cells. These cells have an extraordinary ability to kill cells infected with viruses and cells that have transformed into cancer cells. Thus, natural killer cells constitute a crucial part of the immune response in intracellular infections and cancer.
I study how natural killer cells uses surface receptors to recognize sick cells, and how intracellular signals from these receptors translate into effector responses. The ultimate goal is to gain knowledge that translate into efficent ways to use natural killer cells in immunotherapy treatments.

During my studies, I have gained experience in a broad spectre of laboratory techniques. These techniques include methods to study the phenotype and responses of immune cells, as well as different methods to study DNA, RNA and proteins.