HLA DR, Clone AB3SKU: A-334

General description: 

HLA DR, Monoclonal, clone name AB3; Ab Isotop: IgG2a; Aplication tested: flow cytometry.

Antibodies to HLA-DR are considered essential for the initial evaluation of acute leukaemia, chronic T- and B-cell leukaemia and myeloid leukaemia when used together with a panel of other antibodies but  not intended for tissue typing.
 
HLA-DR antigen is constitutively expressed on antigen-presenting cells, such as B lymphocytes, monocytes and dendritic cells but can also be detected on activated T lymphocytes and activated granulocytes. The antigen has been found expressed in cases of different types of acute lymphoblastic leukaemias, acute myeloid leukaemias except AML-M3, chronic lymphoblastic leukaemias, chronic myeloid leukaemias and B- and T-cell non-Hodgkin’s leukaemias.
 

 

About the scientist

June Helen Myklebust

co-PI, Senior scientist, PhD

The main focus of our research is to study B-cell lymphoma biology, and we perform molecular characterization as well as functional studies. Lymphomas are cancers derived from the cells of the immune system, and most often they arise from B-cells in the lymph nodes. By the means of high throughput analysis of gene expression and genomic and epigenetic alterations in lymphoma samples, we aim to elucidate oncogenetic mechanisms in lymphoma development. We also aim to identify prognostic markers and characterize biologically different subgroups of lymphoma.

We have a strong translational focus with a close collaboration with the lymphoma program in the Hospital and an extensive international collaboration. Several projects are connected to ongoing clinical trials, and we analyze primary patient samples using a broad spectrum of methods.

Selected lymphoma-specific genetic aberrations are followed up by basic cell biology research, using B cell lymphoma cell lines as models. Central techniques include studies of signalling pathways by Western blot analysis and multicolour flow cytometry, confocal microscopy, tissue micro array (TMA), array copy number genetic changes (aCGH), and gene expression profiling.  
 

Group leader: Erlend Bremertun Smeland, PI, MD/PhD

http://ous-research.no/ebsmeland/